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I use this book in my Introduction to Clinical Research course, is clear, comprehensive and easy to follow. I also use the Hulley SB, Cummings SR, Browner WS, et al. (2013) Designing Clinical Research for specific topics and more details.
Essential Concepts in Clinical Research: Randomised Controlled Trials and Observational Epidemiology
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After watching the series I took the opportunity to start the book, so my comment is from the perspective of the series. The book is much more in-depth, far-reaching and terrible. The author succeeds in getting you inside the heads of the people who suffered this terrible accident at times. And those moments are like the worst of nightmares.