Without a doubt the most famous Hanna Barbera franchise outside of course the meddling kids, Originally airing from 1960 –1966 it would end up spawning various cartoons, specials, comics, movies, videogames, crossovers, etc. Originally inspired by The Honeymooners (1955-1956) The Flintstones would end up paving the way for adult animation. as well as breaking rules, Wilma being openly pregnant was a huge deal for animation at the time and to a similar extent Bamm-Bamm being openly adopted by Barney and Betty. The Flintstones was the world's first animated sitcom.