Disappointing.
1) No Verisimilitude at all. This is an American universe, built for Americans with surface level diversity but a complete failure to factor in any diversity of thought or culture outside of recognizing the existence of Libertarians. You could call it an optimistic view of the future and yet the main power finds the perfect habitable world, builds one city and then forces everyone else to go and inhabit glorified asteroids, toxic, fireballs and worlds with giant killer monsters. None of it makes sense. But then every NPC can basically walk around a toxic, irradiated fireball indefinitely without any worry about harm, it's just the player that apparently has to worry about such things.
2) Horrendous, boring and frustrating game mechanics. I did not want to play a survival game. I did not want to play a resource hunting game. That's not why I play Fallout or Elder Scrolls and while those franchises do have resources and base building (Well Fallout does anyway), those games are a lot easier to gather resources in and can largely be ignored. But here a lot of it is basically like doing resource gathering in Mass Effect but without Mass Effects land vehicles.
And why does this universe have no ground vehicles? At least not ones you can use. They want you to manually walk around hazardous planets, gain negative status effects every five minutes by doing it and don't once think that maybe a space buggy would be insanely obvious. The status effects are the worst. Every few minutes it's Hypothermia, Burns, Sprains, etc. And again, these are things no NPC ever has to worry about, just you. Why? Why isn't this optional?
3) The universe is BORING. The multiverse is BORING. Elder Scrolls has Lizard people and Cat People as well as Elves and Humans. Fallout has Supermutants and Ghouls as well as Humans. The game set in space in the distant future just has Humans. Generic, humans that basically all look the same despite the ethnic diversity. Most of the planets look the same too. Most, I found some interesting looking places, but the novelty wears off soon and you are back to the same generic bases, same generic rocks, same generic ship interiors.
99% of the quests are boring fetch quests. The Main companiosn are so much better than the rest they make them largely pointless and yet some of the lesser companions are locked by quest lines. Which when you skip to new universes will become locked again.
Finally the multiverse idea is not what it cracked up to be and really feels like an afterthought. Which is odd since it's the entire point of the main quest. The New Game+ has a few minor dialogue comments which outside the main quest line (Which you can skip anyway) has basically no impact. It's just you say something, they go "Oh" and then you both act like you are a clueless newbie again that hasn't done this thing 100 times already. Which takes me back to the first point. I've never been so aware that I was playing a game before with a Bethesda RPG.
So Why did I even give it 2 stars? Because there are some good things here. A few needles in the haystack for random events or quests that actually had me interested. The combat is reasonable and Neon does look cool, even though it was blatantly "Let's do a cyberpunk city", Much like Akilla is "Let's do a wild west city". Honestly the main reason I'm giving 2 stars is since you can't give zero, one is the minimum and this isn't the worst game ever. It may be Bethesda's worst game ever though!