While A bit difficult to understand at first (thanks to the reviews which rated this a "sci-fi thriller"), it didn't take long to understand that Owen Wilson is a tormented soul in 'Bliss,' suffering from delusions and addicted to whatever drugs for which he can't get his prescription filled.
I noted how the sign for the Rehab facility makes cameo appearances throughout the movie.
As a sci-fi, this one's a bust. As a thought-provoking look into the mind of an addict, it's an A+.