Very curious whether non-manga fans will have trouble staying with the plot. It is one of the few mangas I read (a few times) and I kept thinking "wow...they put EVERYTHING in, for better or worse". I loved it, the disconnect and relationship between characters and their bodies was awesome, one of the best themes in the manga.
I feel that if I were a 14 year girl it will blow my mind, and I would take martial arts classes next day. Best review I read: "it's Jason Bourne combined with the Little Mermaid!".