Having completed at least 1 clear for each aspect, completed the story and maxing out most trinkets, companions and the mirror. I must say, this game is far too overrated. Enemy designs are very meh, there is very little variety and many boons (power-ups) just don't mesh at all with others where when playing normal runs will affect you much more than other rogue-likes.
Get it if you really want to, be forewarned, it is not a masterpiece or has very good story as most would make you believe.
Enjoyed it at first, but you'll soon find that compared to other rogue-likes, the replayability is... well look, the devs tried to do something but it falls flat.