Get through the intro, that's the hardest part of the game. And don't worry, you can get through the main storyline and you'll almost never have to talk to the handler again, and during the storyline you can space things out or just avoid talking to her in general to reduce the exposure to her chatterbox.
(Someone beneath me said the palicos (cats) are useless, for anyone interested, palicos at first will only occasionally use a thing called a vigorwasp, which heals you, but you can unlock more gadgets, such as a horn that gives buffs, an item stealing boomerang, and more. Another person had qualms with the hitboxes, and to address those, they are actually pretty accurate, and dodging will give some invincibility frames, so it's all about practice and timing. And for air attacks, they always target where you were at the start of the attack, with a little variation, so you just need to move out of the way, then dodge. Most people's grievances with Monster Hunter games seems to be based on the fact that they can't learn timing, but don't let that stop you, because you can play with friends or just strangers on line, with a really helpful community.)
One of the best games I've ever played. For the people who complain about the Handler, it does get better, along with hunts in general as they become more difficult and weapons more varied. Finding friends to play with also is a blast, and I'd recommend MHW as a must buy for any previous Monster Hunter game fans (though it is different) and just a fun game for most people I've talked to. There's 14 weapon categories, all which have their own upgrade tree with over 50 unique upgrades for each weapon. These don't just increase attack, but element types, things like decoration slots (which give boosts to certain things like defense overall, attack when a monster is aggravated, and many more), their own skills that have the same effects as decorations, and weapons like the bowguns, gunlance or greatbow have their own ammo types and effects unique to each tree and version of the weapon.
Each monster has 3 (or 4) types of armor unique to it, with its own skills and decoration slots available, and elemental resistances to go with them.
It can sound like a lot to newcomers, but the game guides you to a point where you can understand the fundamentals, but you will have to get a bit more in depth to really bring out the strengths and weaknesses of builds.
Sorry for the block of text, but if you were to buy one game, this would be an excellent pick.