Medical Xpress - Medical and Health News

Medical Xpress - Medical and Health News

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RNA may act as a built-in off switch for the MLL1 gene-control complex. A key protein, WDR5, binds many RNAs broadly, and when enough RNA accumulates, the complex can dismantle itself and stop promoting gene activity.

Two mpox proteins appear to act like a switch for viral replication. When polymerase binds helicase-primase, it pulls a blocked channel open, allowing the DNA-unwinding machinery to start working.

In mice, an AI-designed BCMA binder gave CAR T cells complete control of tumor growth, while an FDA-approved BCMA design could not limit it. The same work also points to design rules involving charge and amino acid composition, though some targets remained difficult.

Blocking or removing PD-L2 in mice reduced harmful aging cells, lowered inflammatory signals, and improved sugar processing and grip strength. Human aging cells also produced more PD-L2 than younger cells, but whether blocking it can safely help patients remains unresolved.

More than three-quarters of donated lungs offered for transplant are not used. A new device continuously tracks glucose and lactate during ex vivo lung perfusion, potentially giving transplant teams better evidence than hourly lab tests when assessing donor lungs.

Across six blood-protein aging clocks, rentosertib was linked to a younger predicted biological age in patients with idiopathic pulmonary fibrosis. The clearest signal appeared after four weeks at 30 mg twice daily, separate from the dose that worked best for lung disease.

Tirzepatide reduced sleep apnea breathing interruptions by 50% to 63% in Phase III trials, or about 20 to 24 fewer events an hour. Remission reached 42% to 50% after one year, though durability after stopping the drug remains uncertain.

Don't miss a beat! Here are yesterday's top stories: Slow breathing, pink noise, and even altered states under psychedelics and anesthetics point to a striking theme: subtle shifts in rhythm may shape how the brain regulates anxiety, sleep, and consciousness. Alongside that, earlier menopause and a new protein-based MRI approach bring brain aging and hidden cancer into sharper focus, suggesting that timing—of bodily change, diagnosis, and neural activity—may be more revealing than it first appears.

Uncertainty appears to make multitasking harder because the brain starts mixing task-relevant and irrelevant visual information. After a few failed tries, features that are usually encoded separately were no longer kept apart in the same neurons.

A protein-based MRI agent detected invasive lung tumors and metastases as small as 1 millimeter in preclinical studies, earlier than conventional imaging. It targets collagen type I, which is elevated in aggressive tumors and metastatic lesions.