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Mouse tau formed exact copies of human disease-specific folds, accumulating for nine to 12 months even though injected seeds vanished within a week. @nature https://t.co/YO7NRAgPpd
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5 hr
One psilocybin dose was linked to greater social exploration a week later in male mice with OCD-like behaviors: they spent more time investigating an unfamiliar mouse. @MolPsychiatry https://t.co/GnAenPb8gA
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7 hr
Clusters of VEGFR-3 receptor pairs amplify signals for lymphatic vessel growth, adding a layer of control beyond pairing two receptors. @advscinews https://t.co/updAj7rKH7
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9 hr
The protein Piezo1 helps set the length of protective nerve coatings by letting myelin-making cells sense nerve fiber diameter—a key detail in how insulation that influences signal speed takes shape. @PLOSBiology https://t.co/BIqsiVKmvF
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11 hr
Antidepressant-specific brain connection changes appeared in only some patients after one or two weeks of treatment, rather than across everyone taking the medications. @NatMentHealth https://t.co/vCFufqJ6vN
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13 hr
Striatum stimulation increased sensitivity to both rewards and mental effort when people chose whether to tackle paid memory tasks, compared with sham stimulation. https://t.co/8wkZ9mRgA0
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Chronically inhibiting the amygdala prevented OCD-like behavior in mice, where a newly identified connection to a habit-related brain region was abnormally active; treatment targets remain untested. @stonybrooku @neurocellpress https://t.co/RxPC7Q2AhV
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17 hr
Both severe salt restriction and extreme salt intake impaired memory in mice carrying human gut bacteria, with worse short- and long-term memory than mice eating normal amounts of salt. https://t.co/Tm4AbJw2pC
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19 hr
Gut inflammation prompted dormant breast cancer cells to divide in a mouse bone model—a possible trigger for cells that can remain hidden for years. @thecrick @CellReports https://t.co/99AG36NUpt
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1 day
Visceral fat fell 12% with CBL-514 injections versus a 5.7% rise with placebo, four weeks after the last treatment in a small phase 2 trial subgroup. https://t.co/fReBbGzGuc
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Investigational retatrutide at 12 mg produced 18.8% average weight loss over 80 weeks in adults with overweight or obesity and type 2 diabetes, versus 5.1% with placebo. @TheLancet https://t.co/9u4jmvwkPe
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Immune aging accelerates around 40 and again after 60, rather than progressing steadily, with different types of T cells driving each wave of changes. @dukenus @NatureComms https://t.co/5iGH3yCHSx
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Silencing a small group of brain cells reduced predator-scent avoidance in mice given a synthetic cannabinoid, linking these neurons to the drug’s anxiety effects under stress. @northwesternu @NatureComms https://t.co/GUOnV9e46Y
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Early-onset type 2 diabetes went into remission in 54% of participants after 24 weeks of a low-calorie diet and structured exercise, versus 4% with usual care. https://t.co/2nP8ECAMxE
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Lab-grown human pituitary tissue boosted cortisol for six weeks in a macaque without a pituitary gland—the first such success in a primate, though immune rejection limited its function. @NagoyaUniv_info https://t.co/f9gZCc5aHG
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Hearing aids helped 15.34% of adults with hearing loss and mild cognitive problems regain normal cognitive scores over two years, versus 2.36% with health education; dementia prevention remains unproven. @JAMAOto @jamaneuro https://t.co/E1F6d01PUa
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Adolescents taking 12,000 or more steps daily had fewer mental health symptoms a year later than those below 5,000, but the link does not establish cause and effect. @kingscollegelon @jamanetworkopen https://t.co/44VWKXu11k
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Female rats made more liver energy-cycle proteins after endurance exercise, while males modified more existing proteins—a sex-specific response whose cause remains unclear. @MizzouNews @CellReports https://t.co/Yoy053gl4o
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Petrelintide produced 10.7% average weight loss in 42 weeks versus 1.7% with placebo in a Phase II trial, offering a potential obesity treatment that still needs Phase III confirmation. https://t.co/JlfLHp7o3O
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AID-induced mutations virtually disappeared when two proteins, MLLT1 and MLLT3, were removed—even though the mutation-making enzyme remained attached to DNA. @nature https://t.co/LLau2EjLPt
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