Almost insta-quit the game due to the Mouse Cursor not being locked to the main screen. It moves over to any extra screens you have connected outside of the game view, even if you use Full Screen mode. This makes scrolling the viewport with the edge of the screen impossible.
But at least most of the moving around happens with WASD and L-Click & Drag.
Other than that, the game is really fun, the tutorial doesn't leave you in the lurch, and ramps your understanding up quite well, systematically, and you quickly feel like you have a good grasp on what is where in the UI.
Keeping up the air quality for your colony is a bit of an annoying mechanic, but other than that the game provides for hours of fun.
Worth a look if you are a fan of the city builder type games.