Amanda Seyfried is completely miscast, and the tone far too comedic and light-hearted.
Holmes is an extremely intelligent sociopath, and whilst she may be socially awkward, she is also brilliant at reading and manipulating people which is not portrayed accurately here at all.
Based on this show, Holmes was a socially awkward, naive misfit, which is far from the reality of the situation, and almost invites us to sympathise with her, which is completely misplaced.
Holmes also famously has the classic sociopath intense blank stare, which again, was missed in this portrayal.
A disappointing effort at a very intriguing story.