This is easily one of the best shows I've seen in a long time. The acting is excellent and the script is simply amazing. It's about shedding what you don't want/need, establishing boundaries, confronting and healing past trauma, creating deep and emotional friendships, and embracing life, love and humor as a healthy way to face death. Episode 5 is spectacularly well written and directed.
But as evidenced by some of the comments here, if your life is consumed by religion, you're offended by sexual kink or seeing male frontal nudity, or you're a guy easily triggered by feminism and assertive female characters, this series will make you uncomfortable.