Historically generally accurate. Hypatia, a female mathematician, teacher, and rationalist philosopher, is portrayed amidst religious turmoil in the city Alexandria of the Roman Empire of the early 5th century.
All the major religious constituencies of the city, Pagans, Jews, AND Christians, are portrayed in very bad light -- probably not worse than they historically deserved. But this was a time when Christianity was already the official religion of the Empire. As an careerist, former friend and sympathizer of Hypatia, put it, "We're all Christians nowadays".
Hypatia comes to a bad end at the instigation of Cyril, Bishop of Alexandria, who quotes quotes the Epistles of Timothy, (attributed to but likely not written by Paul of Tarsus), regarding the role of women.