I'm thoroughly entertained by this series. I've seen every Star Trek series and every episode, most of them repeatedly over the years, so I'm familiar with the concept. I was cautious at first because Seth MacFarlane is far too crude for the STU.
I'm sold. This series is intriguing for many reasons. I wonder how much of the detail is MacFarlane tweaking Star Trek in the way he thought the series should've gone. It seems to be getting more serious as the show goes on and it keeps getting better. The story lines go along with STU style, Brannon Braga directs a lot of the episodes, many Star Trek series actors have been on the show along with several surprisingly big name actors.
The visual and audio effects are studio film quality as are the alien costumes and set design which is really top notch.
If you're a Star Trek fan at all, this series is worth watching.